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Tramadol: A Potent Analgesic
Pain is the most common cause that patients seek medical treatment for. Pain management is considered the most important professional and ethical duty of medical experts. However, it is a very complicated task because the pathophysiology of pain is very complex and has not been completely understood yet. Many steroidal and non-steroidal anti-inflammatory drugs have been used by people to get relief from pain. Most commonly used painkillers are over the counter drugs which are available without the need of any prescription from a medical professional. These medicines belong to the non-steroidal anti-inflammatory drugs (NSAIDs). But in the case of moderate to severe pain management, a potent analgesic drug is required to treat the pain and inflammation effectively.
Tramadol is sold under different brand names such as Ultram and others. It is a synthetic drug which belongs to the class of opioids. The onset of pain-relieving mechanism usually starts within one hour of administration.
Tramadol is an opioid analgesic drug which is used for the therapy of mild to moderate pain. It was approved for use in 1995 in the United States and works in the brain by changing the way your body feels and responds to pain. It is available in both immediate release and extended release tablet form. Tramadol overdose can cause acute liver failure. Therefore, the dose is especially adjusted for the patients who suffer with liver or renal insufficiencies, though, it is advised to switch to another alternative of this painkiller if the patient has a severe liver condition.
Mechanism of Action
Tramadol belongs to a class of drugs called opioid agonists. It is similar to the chemicals present in our brain called endorphins. These endorphins bind with the different receptors that signal the pain message to the brain. When endorphins bind with these receptors, the sensations of pain become less because the pain signals are hindered travelling from body to the brain.
It mainly acts in the body by these following ways:
- As a synthetic analog of codeine (mu receptor agonist) and it acts a mild opioid agonist
- It also works as a weak serotonin-norepinephrine reuptake inhibitor. Hence as SNRI
- A weak NMDA receptor
Why it is used?
Tramadol is used as a painkiller to relieve mild to moderate pain. In case of severe pain, it is given in the form of combination therapy with some other strong analgesic for better results. In this, a fixed dose of two or more drugs are given to patients that may offer additive or synergistic effect.
Tramadol for Tooth Pain
Tramadol is often used alone or in combination with another analgesic such as acetaminophen to get rid of moderate to severe toothache. According to a study, the results are more productive when this medication is given in combination. For acute pain, a loading dose of fast acting tramadol 100mg is given to the patient orally which will start acting after 20 to 30 minutes of administration. If the pain becomes stagnant or drops off, then maintenance dose is advised by doctor whether by extended release capsule of 100mg once a day or 50mg tramadol tablet.
Tramadol for Kidney Stones
Mostly an over the counter medicine such as Tylenol is given to patient for kidney stones pain. But high dose of Tylenol can damage the liver. Therefore, you should consider a drug with low dose and maximum analgesic effect such as tramadol. You must consult your doctor or pharmacist and tell him about your condition immediately. Talk to him about your pain, any prescribed or over the counter drug you take and any other herbal medicine. If you suffer from renal insufficiency then do not take more than 200 mg tramadol per day.
Tramadol for Migraines
Most of the people take over the counter painkillers such as paracetamol or ibuprofen to relieve the migraine pain. But according to some studies, Tramadol is considered more effective to treat the severe migraine attacks as it is a centrally acting strong opioid analgesic. Therefore, it is often prescribed by physicians in combination with an over the counter drug for the management of migraine. It reduces the symptoms of photophobia and severe headaches related to migraine.
Tramadol for Depression
Generally, tramadol can make you feel relaxed and reduce anxiety. It alleviates the mood by giving relief from pain. Tramadol is structurally similar to some antidepressant drugs such as mirtazapine and venlafaxine these drugs also inhibit the 5HT and norepinephrine reuptake. According to research, because of this similarity tramadol is used as a potential antidepressant for treatment of depression and its related symptoms.
Tramadol for Sleep
As we all know that tramadol is a synthetic analog of opioid and works as a potential antidepressant by making you feel relaxed. Therefore, it is given to patients who are suffering with some sort of stress or psychological issues and are unable to sleep at night (insomniac).
The exact mechanism of action in brain for this purpose is unknown. There are a few research programs going on to properly understand tramadol action to induce sleep in patients.
Tramadol Serotonin Syndrome
Serotonin syndrome is a serious condition which happens due to excessive serotonergic activity. It is usually caused by using any antidepressant alone or in combination with other drugs with serotonergic activity. Tramadol is basically a centrally acting analgesic which works as a partial mu agonist and hence affects serotonin and norepinephrine levels in the brain. A case was reported in 2006 in which a woman ingested excessive amounts of tramadol in combination with some other medications and later suffered from the serotonin syndrome and other severe side effects related to tramadol.
Although tramadol is a good and strong analgesic and helps in pain management, but the patient should be well counseled by the doctor or pharmacist about its side effects before starting this medication.
Tramadol for Arthritis
Arthritis is a word which means joint inflammation, but it is often used to describe more than 200 health conditions that affect the joints. Arthritic pain can start from inflammation of one or more joints or tissues. It is a rheumatic condition. The causes of arthritis can be different, but it is mainly managed by physical and occupational therapy, exercise along with medication such as supplements for recovering bone health and anti-inflammatory drugs. These anti-inflammatory medicines are analgesics which are given in combination to reduce the inflammation and stiffness in tissues thereby relieving the severe pain.
Mostly over the counter NSAIDs (non-steroidal anti-inflammatory drugs) are given to the patients such as naproxen, Tylenol and ibuprofen. But in case of severe pain your specialist may also prescribe you a strong opioid analgesic such as tramadol. The main benefit of using this medicine is that you will get more relief by a smaller dose plus it does not cause any stomach ulcers or internal bleedings that can occur with some NSAIDs.
Tramadol for Fibromyalgia
Fibromyalgia is a chronic condition defined by core symptoms of widespread pain, muscle stiffness, fatigue, sleep disturbance and cognitive dysfunction. It causes severe musculoskeletal pain in body and also affects memory and mood.
Tramadol is a narcotic pain reliever and is used to treat moderate to severe pain in adults. It is often prescribed for patients suffering from fibromyalgia. It is a synthetic opioid receptor agonist with norepinephrine serotonin reuptake inhibitor properties. That is the reason it is prescribed for acute pain conditions such as fibromyalgia. Some other anticonvulsant drugs e.g. pregabalin are also used in combination with tramadol to treat this chronic condition.
Tramadol for Nerve Pain
Nerve pain is also called neuralgia or neuropathic pain. It happens when a disease affects our brain cells or neurons. These nerve cells carry the sensations to the brain. This usually occurs in health conditions such as vitamin B12 deficiency or diabetes.
Typically, an over the counter or prescribed painkiller is given to the patient to relieve the stabbing pain. Tramadol is a potent analgesic which is given to the patient alone or in combination with another drug such as antidepressant or anticonvulsant such as pregabalin when prescribed by the doctor. Some other techniques such as lotions, gels and patches are also used for local pain.
Tramadol for Osteoarthritis
Osteoarthritis is a bone disorder in which the cartilage wears off over the time from the joints. It mostly affects the joints of the knees, hands, hips and spine. Tramadol is the most commonly used opioid which is increasingly prescribed by the physicians for osteoarthritis related pain management. The reason behind this extreme use is that unlike some other NSAIDs, it does not cause any gastrointestinal bleedings or renal issues.
Tramadol Without Prescription
There are many online pharmacies that sell tramadol online without prescription. These sources are called no-prescription online pharmacies. These pharmacies provide you a few benefits such as convenience, cost effectiveness and ability to purchase this medicine easily in case of emergency with any prescription at all. But the risk of inappropriate dose, side effects and poor knowledge about its use. One must be fully aware of how and when to use this medicine if he wants to purchase this medicine online.
Order Tramadol Online
This drug is available online in different strengths e.g. tramadol 50mg, tramadol 100mg etc. Most commonly ordered tramadol is tramadol 100mg.
You can also order tramadol 100mg online from a reliable non-prescription online pharmacy for an easy and quick pain relief.
Tramadol Recreational Dose
Tramadol is a prescription only drug, which means you should not take this on your own. It belongs to the class of narcotic drugs and is highly addictive in nature. People use it for recreational purposes also, but it is very necessary to know about its safe dosage. Otherwise, it will lead to drug abuse and you will have to bear the consequences later.
People often crush the tramadol tablets and snort the powder with a pipe. Although it is not as strong as heroin, but it is addictive. Tramadol is a strong painkiller, but it also makes you feel high, relaxed and happy for some time. After that, side effects will kick in that will make you drowsy, confused, itchy, sweaty or constipated. The severity of these side effects depends on how much quantity is consumed. Tramadol dose should not exceed 400mg/day. Overdose of this drug can be fatal and requires immediate medical attention.
Tramadol 100mg Dosage Regimen
Tramadol 100 mg oral tablet is given to different age group of people in different dosages and frequencies as per their need.
Doses for Moderate to Severe Pain
Tramadol 100mg dosage for children (at age 0–16 years)
It is not clear if this form of tramadol is safe to use and effective for children younger than 17 years. Therefore, it should not be prescribed to children of this age group.
Tramadol dosage for kids (ages 15–17 years)
Normal dose: 50–100 mg every 4 to 6 hours as per need
Maximum dosage should not exceed 400 mg per day.
Tramadol 100mg dosage for adults (ages 18–60)
The loading dose may be increased from 100 mg to 200 mg/day.
Maintenance dose remains 50–100 mg every 4–6 hours as per requirement.
Maximum dosage should not exceed 400 mg per day.
Senior dose regimen (ages 65 years and older)
The liver and kidneys of older people may not work as fine as they used to. This can cause your body to process drugs more slowly than normal. As a result, more amount of drug stays in your body for a longer period of time. This raises your risk of adverse effects.
Your doctor may start you on a lower dose of the drug. This can help keep levels of this drug from building up too high in your system.
If you are older than 75 years, your maximum dose of the immediate-release tablet of tramadol is 300 mg per day.
If you have severe renal insufficiency, your doctor will probably prescribe you 50–100 mg every 12 hours. The maximum dose remains 200 mg per day.
If you have severe hepatic issue, your doctor will likely prescribe you 50 mg every 12 hours like above.
No doubt tramadol is a great analgesic, but the main side effect is that the opioid receptors agonists such as tramadol cause nausea, dizziness and other agonizing symptoms. It is normal for this sort of symptoms to go away within 1 to 2 weeks, but you should talk to your doctor if these side effects persist or become complicated.
Tramadol Side Effects
Tramadol oral tablet may cause some side effects, especially in the case of long-term treatments. One of its most common side effect is drowsiness. You should not drive, do high intensity workout, or operate any heavy machinery until you are clear about how this drug affects your body and brain. Tramadol can sometimes also cause other mild to moderate side effects.
Most common side effects
Some of the most common side effects of tramadol include the following:
- Mild headache
- Vomiting and nausea
- Lack of energy or fatigue
- Sweating and dry mouth
- Stomach discomfort
In most cases these effects are mild and may go away within 5 to 7 days or a couple of weeks. If they are more severe or do not go away, you must talk to your doctor or pharmacist.
Order Tramadol Online
Tramadol is basically a controlled substance. Therefore, it is only available if prescribed by a medical professional. It is available in all chain pharmacies. But now it is also available through different online chain pharmacies. So, if there is no pharmacy near you then no need to worry. You can order tramadol online from a reliable online source to get relief from your pain.